Thursday, October 6, 2016

Karvol Decongestant Drops (Reckitt Benckiser Healthcare (UK) Ltd)





1. Name Of The Medicinal Product



Karvol Decongestant Drops


2. Qualitative And Quantitative Composition


















Active Ingredients




% W/V




Chlorobutanol Hemihydrate Ph Eur




0.50




Levomenthol Ph Eur




7.90




Pine Oil Sylvestris




2.00




Terpineol BP




14.80




Thymol Ph Eur




0.70




Pumilio Pine Oil




22.90



3. Pharmaceutical Form



Inhalation vapour, liquid



4. Clinical Particulars



4.1 Therapeutic Indications



For the symptomatic relief of nasal congestion and colds in the head.



4.2 Posology And Method Of Administration



For older children and adults:



For relief throughout the night: sprinkle 6 drops onto bedding or handkerchief nearby but avoiding direct skin contact.



Daytime: sprinkle 6 drops onto a tissue or into a pint of hot water and inhale the vapours freely.



For young children:



For daytime use and relief throughout the night: sprinkle 6 drops onto a handkerchief tied down securely in the vicinity but out of reach of the child..



Elderly: There is no need to modify the administration of this preparation for use by the elderly.



Children under 3 months: Not recommended for children under 3 months.



4.3 Contraindications



Children under 3 months of age



4.4 Special Warnings And Precautions For Use



Avoid contact with the eyes and prolonged contact with the skin.



If symptoms persist consult your doctor.



Keep all medicines out of the reach of children.



For inhalation only.



Do not put drops directly in mouth or nose.



4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction



No clinically significant interactions known.



4.6 Pregnancy And Lactation



The safety in pregnancy and lactation has not been established but it is not expected to constitute a hazard.



4.7 Effects On Ability To Drive And Use Machines



No adverse effects known.



4.8 Undesirable Effects



None known.



4.9 Overdose



Symptoms of massive overdose by ingestion include nausea, vomiting, colic, headache, dizziness, a feeling of warmth, delirium, muscle twitching, epileptiform convulsions, depressed respiration, CNS depression and coma. Initial treatment consists of emptying the stomach by lavage and aspiration. Administer a saline laxative such as sodium sulphate and activated charcoal by mouth. Convulsions may be controlled with diazepam or thiopental sodium.



5. Pharmacological Properties



5.1 Pharmacodynamic Properties



Chlorobutanol, levomenthol, pine oil, terpineol and thymol are volatile substances and are thought to produce an irritant effect on the respiratory tract, possibly via a nasal/pulmonary arc.



5.2 Pharmacokinetic Properties



Not applicable.



5.3 Preclinical Safety Data



There are no preclinical safety data of relevance to the consumer.



6. Pharmaceutical Particulars



6.1 List Of Excipients



Macrogol Stearate,



Cinnamon Oil,



Polysorbate 80,



Polyethylene Glycol 400,



Triacetin.



6.2 Incompatibilities



Not applicable.



6.3 Shelf Life



24 months.



6.4 Special Precautions For Storage



Do not store above 25°C.



6.5 Nature And Contents Of Container



The liquid is contained in an amber glass bottle fitted with a combined all in one polyethylene/polypropylene dropper and a tamper evident child resistant polypropylene cap, or a non child resistant polypropylene cap. The bottle is presented in a cardboard carton.



6.6 Special Precautions For Disposal And Other Handling



Whilst applying drops ensure that the dropper bottle is held vertically.



7. Marketing Authorisation Holder



Reckitt Benckiser Healthcare (UK) Limited



Dansom Lane



Hull



HU8 7DS



United Kingdom



8. Marketing Authorisation Number(S)



PL 00063/0406



9. Date Of First Authorisation/Renewal Of The Authorisation



08 May 1997



10. Date Of Revision Of The Text



25 January 2008




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